CHU Bichat-Claude Bernard Investigators (France) Study Hidradenitis Suppurativa and Conclude a Food Intolerance & Gut Dysbiosis Link

CHU Bichat-Claude Bernard Investigators (France) Study Hidradenitis Suppurativa and Conclude a Food Intolerance & Gut Dysbiosis Link

CHU Bichat-Claude Bernard clinical investigators confirmed from an analysis of patients there in France that Hidradenitis Suppurativa appears to be linked to food intolerance and gut dysbiosis.

TrialSite News has a large readership base struggling with Hidradenitis Suppurativa, and our research team probes for studies that may be of interest.

A Complex Disorder

A complex disorder, no one is certain as to the true cause. There are known associations between HS and Crohn’s disease, an autoimmune disease diagnosed with the presence of Anti-Saccharomyces cerevisiae antibodies of the IgG family and hence suggests that a considerably greater complexity than a simple infectious disorder is involved. 

The Study

The authors of this study sought to report on patients’ characteristics and the outcome of 6 years of a yeast (Saccharomyces cerevisiae) exclusion diet and surgery in the treatment of HS.

The team analyzed 185 HS patients utilizing a self-evaluative questionnaire.  The investigators treated 37 of the patients right in their center following their specific protocol.  The other 148 study subjects were members of a support group for patients with HS treated by other centers in France.

Findings

The team found that 80% of the patients had the onset HS before the age of 30 and that females were afflicted far more than males (3.34:1) in this French study population; HS patients are overwhelmingly smokers (74%) and 5% were diagnosed with Crohn’s disease.

Within the diet group, 70% saw improvements in their HS symptoms while 81% did so in less than 6 months! Interestingly, once study participants consumed food containing yeast within one week, they experienced recurrences of skin lesions. Upon immunologic testing revealed intolerances among this patient group to yeast, wheat, and cow’s milk in 20%, 29% and 23% of patients respectively.

Conclusion

The study team concluded that the analysis confirmed the stabilization and regression of HS with subject diet, presumably by lowering amounts of local and systemic inflammation, leading to a less invasive operative treatment. These new findings appear to link HS to food intolerance and gut dysbiosis

About CHU Bichat-Claude Bernard 

CHU Bichat-Claude Bernard is located in Paris and is operated by the Assistance Publique– Hôpitaux de Paris (APHP). Founded in 1881, it is now also a teaching hospital of Paris Diderot University.

Lead Research/Investigator

C. Aboud, Plastic Surgery Unit, CHU Bichat-Claude Bernard, Paris, France

N. Zamaria, Plastic Surgery Unit, CHU Bichat-Claude Bernard, Paris, France

C Cannistra, Plastic Surgery Unit, CHU Bichat-Claude Bernard, Paris, France