ChristianaCare Study Discovers Radiation-triggered Inflammation can Drive Triple-Negative Breast Cancer

ChristianaCare Study Discovers Radiation-triggered Inflammation can Drive Triple-Negative Breast Cancer

A study led by an investigator with ChristianaCare’s Helen F. Graham Cancer Center & Research Institute concludes that the radiation used to treat breast cancer by killing cancer cells can cause side effects, including inflammation, which in turn can introduce a contrary effect by promoting the survival of triple-negative breast cancer cells.

Triple-Negative Breast Cancer

The fastest growing type of breast cancer, triple-negative breast cancer now represents about 15-20% of all breast cancers. It is a breast cancer that doesn’t express genes for estrogen receptor (ER), progesterone receptor (PR) and HER2/neu, making it difficult to treat given that most hormone therapies target one of the three receptors. Hence, this form of cancer often requires combination therapies.  

Delaware was the location of the study and represents a hot spot for triple-negative breast cancer. Rates in “The First State” are the highest nationwide according to the ChristianaCare news release.

Study

Published online in the International Journal of Radiation Biology and led by Jennifer Sims-Mourtada, PhD, director of Translational Breast Cancer Research at ChirstianaCare’s H...

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