Today in Science, researchers at the University of Pittsburgh School of Medicine describe a new method to extract tiny but extremely powerful SARS-CoV-2 antibody fragments from llamas, which could be fashioned into inhalable therapeutics with the potential to prevent...
Preclinical Research
Category
Bodoland University Researcher Suggests In Silica Study Points to Ivermectin Promise Targeting SARS-COV-2
A researcher from Bodoland University reports on a study investigating the binding property of ivermectin on four critical drug targets, including 1) spike protein, 2) RNA-dependent RNA polymerase, 3) 3-chymotrypsin-, and 4) papain-like proteases of SARS-CoV-2, the...
Washington University School of Medicine, St. Louis COVID-19 Nasal Vaccine Works in Mice, Primates Next
Prominent Scientists at the Washington University School of Medicine in St. Louis are working on a nasal COVID-19 vaccine that apparently proves effective in mice susceptible to the coronavirus. The recent study reveals that the early-stage, experimental vaccine can...
University of Minnesota Investigators: Apilimod 5X More Potent Against COVID-19 than Remdesivir in Cell Culture
Researchers led by Ricardo Battaglino, PhD, with the University of Minnesota Medical School, see significant promise for the anti-cancer drug apilimod. The university recently reported that early results show that apilimod is five times more effective in treating cell...
Penn State Secures $1.85m to Pursue Important Preclinical Research Examining How Dysfunctional Brain Hubs Connect to Mental Disorders
That 45 million Americans struggle with mental health issues is of crisis proportion is not an understatement. The human and economic is staggering: new and improved treatments are required. Hence the TrialSite is pleased to announce that Penn State...
UT Southwestern Preclinical Research Points to Atovaquone as Possible COVID-19 Treatment
University of Texas Southwestern Medical Center researchers have identified a potential COVID-19 treatment in preclinical research activity targeting COVID-19, and they are now making the moves to secure the necessary approvals to investigate its use in North...
Potentially Significant UCSD Breakthrough with Potential to Treat Parkinson’s Disease & Other Neurodegenerative Disorders
A scientist and colleagues from the University of California San Diego School of Medicine are on to an exciting discovery that could someday lead to new therapeutic options to eradicate Parkinson’s disease symptoms and possibly other neurodegenerative disorders. What...
UB, UCSF & UNC Make Melatonin Discovery to Someday Fix Biological Clocks
A collaborative research team including members from University of California, San Francisco (UCSF), the University of North Carolina at Chapel Hill (UNC), and University of Buffalo (UB) have utilized a vast and novel computational library the first molecules that can...
Queen Mary University of London Opens up New Organs-on-Chips Research Center
Queen Mary University of London has opened up a new research center aiming to revolutionize medical research and drug development using microengineered Organs-on-Chips. What are Organs-on-Chips? These devices contain tiny hollow channels lined by human living...
Study at Cincinnati Children’s Hospital Medical Center Opens New Avenues for More Effective Autoimmune Therapies
Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases. In a study published online Dec. 17, 2019, researchers at Cincinnati...
University of Pittsburgh & NIAID-Led Preclinical Study Reveals Intravenous TB Vaccine Highly Effective
A recent University of Pittsburgh-led study reveals that tuberculosis (TB) vaccines could be dramatically more effective if they are given intravenously rather than a simple shot into the skin and muscle. TB is the world’s deadliest disease, killing 1.5 million people...
NIAID Experimental New Zika Vaccine Improves Fetal Outcomes in Macaque Model
Preclinical investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institute of Health (NIH) and collaborators from the University of California, Davis, Duke University, and the University of California, Los Angeles,...
Purdue-Led U.S. and Chinese Research Team Identify New Potential Approach for Treating Inflammation
Purdue University researchers have discovered miR-199 (a type of “microRNA), a genetic molecule, which reduces the migration of neutrophils and hence possibly relieve inflammation without compromising the immune system. This is an important potential breakthrough...
University of Arizona Not Only Showcases Potential of Aliskiren for Extending Survival in Heart Failure but Also Files Patent for New Way to Measure Edema
Preclinical research at the University of Arizona College of Medicine—Phoenix reveals that Aliskren, a drug that inhibits the enzyme that regulates blood pressure, can delay the progression of congestive heart failure and lengthen survival rates. The team also...
Yale Selected to Participate in Stroke Preclinical Assessment Network (SPAN) to Study Ischemic Stroke Treatments
Yale Department of Neurology received a $4 million grant from the National Institutes of Health to assess acute ischemic stroke treatments in rodent models. They are participating with other institutions in the Stroke Preclinical Assessment Network or SPAN. The...
In Preclinical Studies Age Impacts the Efficacy of Immune Checkpoint Blockade (ICB) for Breast Cancer
A recent preclinical study using younger and older mice with triple-negative breast cancer (TNBC) sponsored by Boston-based Brigham and Women’s Hospital, the Dana Farber Cancer Institute and Harvard Medical School found that age does, in fact, affect the efficacy of...
Biomedical Research may be Damaged by White House China Tariffs on Monkeys
New Trump tariffs may damage U.S. biomedical research, forcing animal testing lab operations to China. What is going on? The Trump Administration will impose a 15% levy on $300 billion worth of Chinese imports as he escalates a U.S.-China trade war. CNBC reports that...
Indonesian Bajakah Tree Cures Cancer in Rats in High School Students’ Study: Are they on to Something?
Two Indonesia high-school students used a local lore of a plant’s medicinal properties in their own form of a clinical study. Attending Palangka Raya State High School in Central Kalimantan, the duo presented their evidence last month at a conference in Seoul, South...
Tel Aviv University & Univ. of Lisbon Develop Nano-Vaccine Against Melanoma & Sensitizes the Immune System to Immunotherapies
Tel Aviv University’s Professor Ronit Satchi-Fainaro and University of Lisbon’s Helena Florindo have developed an effective nano-vaccine against melanoma that also sensitizes the immune system to immunotherapies that shows results in mice—could it work in humans? The...
Stanford Researchers Shrink Stroke Damage in Mice by Calming Immune Cells
Stanford scientists actually shrink stroke damage in mice by calming immune cells outside the brain. Rather than trying to fix stroke-damaged nerve cells, Stanford scientists took aim at a set of first-responder immune cells that live outside the brain to the site of...