Belgium Study Results Suggest Kidney Failure Patients on Dialysis Benefit from Higher Dose COVID-19 Vaccine

A group of Belgium researchers led by An S. De Vriese, MD, PhD. AZ Sint-Jan Brugge, Belgium) conducted a prospective observational study of the impact of COVID-19 immunization on patients with kidney failure presently receiving dialysis. Published in the Journal of the American Society of Nephrology (JASN), the study team’s focus concerns those individuals on dialysis with less than stellar COVID-19 vaccine responses. Given this vulnerable patient cohort is at greater risk for COVID-19 vaccination strategies are important.

Given patients with kidney failure on dialysis face greater risks from COVID-19, Belgium-based investigators sought to better understand the predictors and forces and influences of their particular antibody and cellular reactions to the Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) COVID-19 vaccine prospectively.  An important topic as death rates from SARS-CoV-2, the virus behind COVID-19, are high in patients with kidney failure who are on dialysis.

The Study

The Belgium investigators led a multicenter study involving 543 patients on hemodialysis as well as 75 healthy individuals (e.g. normal kidney function) at week 4 and 5 and ag...

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