Argentinian Preclinical Animal Research Reveals Potential Ivermectin-based Nasal Spray Targeting SARS-CoV-2

Argentinian Preclinical Animal Research Reveals Potential Ivermectin-based Nasal Spray Targeting SARS-CoV-2

Multiple research centers, including universities and Laboratorio Elea Phoenix (Elea Laboratories) from Argentina, recently concluded preclinical animal research investigating the safety and pharmacokinetic attributes of an experimental, novel nasal spray-based product developed to inhibit and suppress SARS-CoV-2, the virus behind COVID-19. This investigational nasal formulation was administered in an animal model (pig) and involves the use of Ivermectin, the macrocyclic lactone-based medication that evidences antiviral effects against several distinct positive-single-sense-strand RNA viruses, including SARS-CoV-2. More specifically, the Argentinian preclinical researchers developed a high-concentration nasal formulated investigational product for administration in a primary location for concentrated SARS-CoV-2 penetration and replication—the nasopharyngeal tissue. These animal studies revealed that the experimental formula and delivery method was not only well tolerated but also safe with no adverse events identified. This research represents a preclinical effort; and for experimental use in humans in that nation, the researchers would need to file for an equivalent investigation...

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