The American Heart Association and the Duke Clinical Research Institute (DCRI) have formed a strategic alliance in the pursuit of conducting pragmatic randomized clinical trials with a cardiovascular focus. With an emphasis on ultimately reducing patient suffering, the duo will explore best practices when it comes to cardiovascular pragmatic trials.
The two organizations will work hand-in-hand to tap into and capitalize on existing, real-world national registries. Premised on data registry and quality improvement programs, the partnership will apply the most up-to-date evidence-based treatment guideline to improve patient outcomes. The two organizations will leverage the AHA’s deep, rich and robust data repositories—based on connectivity to over 2,000 hospitals and millions of patient records and combine with DCRI’s extensive real-world data research experience—and represents a future research model for pragmatic trials. Duke brings extensive experience in conducting pragmatic trials.
A Leader in Pragmatic Trials
A leader in pragmatic approaches in clinical research, the DCRI, in collaboration with PCORnet, pioneered the ADAPTABLE study, which recently completed enrollment of 15,000 patients using real-world data from electronic health records at the many hospitals and health systems they partner with. Meanwhile, AHA’s program will contribute and inform a joint effort to design pragmatic clinical trials.
CCRI represents an organic partner to apply pragmatic clinical design methods in combination with AHA’s rich and robust Get With The Guidelines program.
What is AHA’s Get With The Guidelines®?
The AHA, a leading voluntary health organization devoted to a world of longer, healthier lives, collects data from more than 2,000 hospitals in the GWTG quality improvement programs. AHA and DCRI will collaborate to design and conduct pragmatic randomized clinical trials in existing real-world nationwide registries. The two also seek to leverage the strategic alliance to implement best practices to treat cardiovascular illness, improve outcomes, and reduce suffering.
Consisting of five modules with a focus on patient conditions (stroke, heart failure, A Fib, resuscitation, and coronary heart disease), each module shares the goal of improving patient care by promoting adherence to the latest treatment guidelines.
Jonathan Piccini, MD, MHS, the principal investigator of the GWTG analytic center at the DCRI