AbbVie and University of Illinois Chicago Develop Novel Device to Screen Advanced Crystalline Materials

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The University of Illinois Chicago and AbbVie, Inc. researchers have developed a novel device that will help scientists and pharmaceutical companies more efficiently screen and test formation of drug substance—active pharmaceutical ingredient.

Who are the Inventors

Meenesh R Singh, an associate professor with UIC’s chemical engineering department, along with UIC graduate student Paria Coliaie and AbbVie scientists Manish S. Kelkar and Nandkishor K Nere.

What did they Develop?

The team developed a controlled microfluidic crystallization device to improve the screening process that pharmaceutical companies use to identify the most stable crystalline form of API and to scale up the crystallization of stable form.

What is the Title of the Study?

Continuous-Flow, Well-Mixed, Microfluidic Crystallization Device for Screening of Polymorphs, Morphologies, and Crystallization Kinetics at Controlled Supersaturation.”

Why is this Relevant?

First, it takes on average about 10 years and $1+ billion to develop a new drug. A significant portion of the 10 years is invested in process development, along with ongoing clinical trials, where scientists screen the different poly...

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