As reported in EurekAlert! researchers from Denmark’s Aarhus University have unveiled cellular defects leading to the rare disease hereditary angioedema (HAE). This understanding is an important step towards gene therapy for patients. This disorder affects approximately one in 50,000 people. The condition is typically first noticed in childhood. Type I and II affected females and males equally. Type III affects females more often than males. When the airway is involved, without treatment, death occurs in about 25 percent of those diagnosed. With treatment, outcomes are generally positive.
Jacob Giehm Mikkelsen from the Department of Biomedicine