Aarhus University Hospital Led Study Indicates COVID-19 Patients Have Robust Natural Immune Response Regardless of Disease Severity

Aarhus University Hospital Led Study Indicates COVID-19 Patients Have Robust Natural Immune Response Regardless of Disease Severity

A group of researchers out of Denmark led by Aarhus University Hospital’s infectious disease department conducted a study involving 203 COVID-19 infected patients between the dates of April 3 to July 9th, 2020. These participants had a range of severity from asymptomatic to more severe. By collecting plasma, serum, and PBMCs to analyze each patient’s specific antibody response via a “Meso Scale analysis” involving COVID-19 strain, ACE2 competition, IgA ELISA, and other elements the team compared immunological outcomes among severity groups within the overall study cohort combined with 10 pre-pandemic COVID-19 negative controls. The Danish team found that the COVID-19 patients overwhelmingly generated SARS-CoV-2-specific antibodies (99%) while specific coronavirus and spike -ACE2 receptor interaction blocking was recorded in 95% of the cases. Moreover, the investigators observed a significant positive correlation (r=0.7804) between spike-ACE2 blocking antibody titers and neutralization potency. The Danish team reported on clear and quantifiable novel coronavirus-specific CD8+ T-cell responses in 90% of  HLA-A2+ individuals. The study authors argue that at least in this study a grea...

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