Recently, investigators from Thailand studied the cardiovascular effects of myocarditis as well as pericarditis post vaccine administration with the Pfizer-BioNTech mRNA vaccine called BNT162b2 in Thai adolescents. Led by Chayasin Mansanguan at Mahidol University, one of Thailand’s top-ranked public research-focused universities, the study team designed the prospective cohort study involving participants between the ages of 13 to 18 years old and above who received their second dose of the BNT162b2 product. What was the cardiac manifestation among these subjects? As reported in a preprint upload, the team collected various data from demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms. Overall the study team enrolled 314 participants; of these, 13 participants were lost to follow-up, leaving 301 participants for analysis. The most common cardiovascular effects were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessment. Cardiovascular effects were found in 29.24% of patients, including tachycardia, palpitation, and myopericarditis. Myopericarditis was discovered in one patient post the mRNA jab, while two subjects were diagnosed with suspected pericarditis, and four of the participants were diagnosed with suspected subclinical myocarditis. The authors concluded that significant cardiovascular events ensue after mRNA COVID-19 vaccination with the Pfizer-BioNTech product. Overall, any cases of myopericarditis post the jab were most often mild in nature—all cases were fully recovered within two weeks. The authors do recommend continued monitoring of adolescents receiving the Pfizer-BioNTech mRNA vaccine.
This study was registered on clinicaltrials.gov (NCT05288231) titled “Cardiac Manifestation in Adolescent After Pfizer COVID-19 injection in Thailand.”
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